Research OverviewProtein Tyrosine Phosphatases Protein Tyrosine Phosphatases (PTP) play important roles in cellular signaling networks. PTP are enzymes that remove phosphate groups from phosphorylated tyrosine residues of proteins. Although it was thought that PTP simply reverse the effects of protein tyrosine kinases which add phosphates, there is now evidence that PTP play a more active role in this important cellular process. | Research DescriptionResearch Area: Genomics and Proteomics Research Specialty: Functions of protein tyrosine phosphatases
Functions of protein tyrosine phosphatases Protein tyrosine phosphorylation is a dynamic and low-abundant posttranslational modification that plays critical roles in many biological processes including cell growth, proliferation, and differentiation. The appropriate level of protein tyrosine phosphorylation in vivo is maintained by both protein tyrosine kinases (PTKs) and protein... Complete Information... |
Representative PublicationsLi SW*, Zeng DX, Chemo-Enzymatic Enrichment of Phosphotyrosine-Containing Peptides, Angewandte Chemie Intrenational Edition, in press, 2007 Li SW*, Zeng DX, CILAT-A New Reagent for Quantitative Proteomics, Chemical Communications, DOI: 10.1039/b700109f, 2007 (Highlight in Chemical Technology, 4, T28, 2007) Li SW, Marthandan N, Bowerman D, Garner HR, Kodadek T*, Photolithographic Synthesis of Cyclic Peptide Arrays Using a Differential Deprotection Strategy, Chemical Communications, 5, 581-583, 2005
Complete Listing... |
