L. Deng, R.J. Langley, P.H. Brown, G. Xu, L. Teng, Q. Wang, M.I. Gonzales, G.G. Callender, M.I. Nishimura, S.L. Topalian and R.A. Mariuzza. Structural basis for recognition of mutant self by a tumor-specific, MHC class II-restricted T cell receptor. Nature Immunol. 8, 398-408 (2007).

S. Cho, Q. Wang, C.P. Swaminathan, D. Hesek, M. Lee, G.-J. Boons, S. Mobashery and R.A. Mariuzza. Structural insights into the bactericidal mechanism of human peptidoglycan recognition proteins. Proc. Natl. Acad. Sci. USA 104, 8761-8766 (2007).

R. Guan and R.A. Mariuzza. Peptidoglycan recognition proteins of the innate immune system. Trends Microbiol. 15, 127-134 (2007).

J. Dam, J. Baber, A. Grishaev, P. Schuck, E.L. Malchiodi, A. Bax and R.A. Mariuzza. Variable dimerization of the Ly49A natural killer cell receptor results in differential engagement of its MHC class I ligand. J. Mol. Biol. 362, 102-113 (2006).

M.M. Fernndez, R. Guan, C.P. Swaminathan, E.L. Malchiodi and R.A. Mariuzza. Crystal structure of staphylococcal enterotoxin I (SEI) bound to a human MHC class II molecule. J. Biol. Chem. 281, 25356-25364 (2006).

C.P. Swaminathan, P.H. Brown, A. Roychowdhury, Q. Wang, R. Guan, N. Silverman, W.E. Goldman, G.-J. Boons and R.A. Mariuzza. Dual strategies for peptidogylcan discrimination by peptidoglycan recognition proteins (PGRPs). Proc. Natl. Acad. Sci. USA 103, 684-689 (2006).

K. Natarajan, A. Hicks, J. Mans, H. Robinson, R. Guan, R.A. Mariuzza and D.H. Margulies. Crystal structure of the murine cytomegalovirus MHC-I homolog m144. J. Mol. Biol. 358, 157-171 (2006).

L. Deng and R.A. Mariuzza. Structural basis for recognition of MHC and MHC-like ligands by natural killer cell receptors. Semin. Immunol. 18, 159-166 (2006).

Y. Li, Y. Huang, J. Lue, J.A. Quandt, R. Martin and R.A. Mariuzza. Structure of a human autoimmune T cell receptor bound to a myelin basic protein self-peptide and a multiple sclerosis-associated MHC class II molecule. EMBO J. 24, 2968-2979 (2005).

S. Cho, C.P. Swaminathan, J. Yang, M.C. Kerzic, R. Guan, M.C. Kieke, D.M. Kranz, R.A. Mariuzza and E.J. Sundberg. Structural basis of affinity maturation and intramolecular cooperativity in a protein-protein interaction. Structure 13, 1775-1787 (2005).

L. Deng, C.A. Velikovsky, C.P. Swaminathan, S. Cho and R.A. Mariuzza. Structural basis for recognition of the T cell adaptor protein SLP-76 by the SH3 domain of phospholipase Cgamma1. J. Mol. Biol. 352, 1-10 (2005).

Y. Li, Y. Huang, C.P. Swaminathan, S.J. Smith-Gill and R.A. Mariuzza. Magnitude of the hydrophobic effect at central versus peripheral sites in protein-protein interfaces. Structure 13, 297-307 (2005).

A. Balbo, K.H. Minor, C.A. Velikovsky, R.A. Mariuzza, C.B. Peterson and P. Schuck. Studying multiprotein complexes by multisignal sedimentation velocity analytical ultracentrifugation. Proc. Natl. Acad. Sci. USA 102, 81-86 (2005).

J.B. Ames, V. Vyas, J.D. Lusin and R.A. Mariuzza. NMR structure of the natural killer cell receptor 2B4 (CD244): implications for ligand recognition. Biochemistry 44, 6416-6423 (2005).

R. Guan, A. Roychowdhury, B. Ember, S. Kumar, G.-J. Boons and R.A. Mariuzza. Structural basis for peptidoglycan recognition by peptidoglycan recognition proteins. Proc. Natl. Acad. Sci. USA 101, 17168-17173 (2004).

R. Guan, E.L. Malchiodi, Q. Wang, P. Schuck and R.A. Mariuzza. Crystal structure of the C-terminal peptidoglycan-binding domain of human peptidoglycan recognition protein Ialpha. J. Biol. Chem. 279, 31873-31882 (2004).

S. Cho, C.A. Velikovsky, C.P. Swaminathan, J.C.D. Houtman, L.E. Samelson and R.A. Mariuzza. Structural basis for differential recognition of tyrosine phosphorylated sites in the linker for activation of T cells (LAT) by the adaptor Gads. EMBO J. 23, 1441-1451 (2004).

J. Dam, R. Guan, K. Natarajan, N. Dimasi, L.K. Chlewicki, D.M. Kranz, P. Schuck, D.H. Margulies and R.A. Mariuzza. Variable MHC class I engagement by Ly49 NK cell receptors revealed by the crystal structure of Ly49C bound to H-2Kb. Nature Immunol. 4, 1213-1222 (2003).

J. Yang, C.P. Swaminathan, Y. Huang, R. Guan, S. Cho, M.C. Kieke, D.M. Kranz, R.A. Mariuzza and E.J. Sundberg. Dissecting cooperative and additive binding energetics in the affinity maturation of a protein-protein interface. J. Biol. Chem. 278, 50412-50421 (2003).

Y. Li, H. Li, F. Yang, S.J. Smith-Gill and R.A. Mariuzza. X-ray snapshots of the maturation of an antibody response to a protein antigen. Nature Struct. Biol. 10, 482-488 (2003).

E.J. Sundberg, P.S. Andersen, P.M. Schlievert, K. Karjalainen and R.A. Mariuzza. Structural, energetic and functional analysis of a protein-protein interface at distinct stages of affinity maturation. Structure 11, 1151-1161 (2003).

Y. Li, M. Urrutia, S.J. Smith-Gill and R.A. Mariuzza. Dissection of binding interactions in the complex between the anti-lysozyme antibody HyHEL-63 and its antigen. Biochemistry 42, 11-22 (2003).

E.J. Sundberg and R.A. Mariuzza. Molecular recognition in antigen-antibody complexes. Adv. Protein Chem. 61, 119-160 (2002).

N. Dimasi, M.W. Sawicki, L.A. Reineck, Y. Li, K. Natarajan, D.H. Margulies and R.A. Mariuzza. Crystal structure of the Ly49I natural killer cell receptor reveals variability in dimerization mode within the Ly49I family. J. Mol. Biol. 320, 573-85 (2002).

E.J. Sundberg, H. Li, A.S. Llera, J.K. McCormick, J. Tormo, P.M. Schlievert, K. Karjalainen and R.A. Mariuzza. Structures of two streptococcal superantigens bound to TCR beta chains reveal diversity in the architecture of T cell signaling complexes. Structure 10, 687-699 (2002).

K. Natarajan, N. Dimasi, J. Wang, R.A. Mariuzza and D.H. Margulies. Structure and function of natural killer cell receptors: multiple molecular solutions to self, non-self discrimination. Annu. Rev. Immunol. 20, 853-885 (2002).

P.S. Andersen, P. Schuck, E.J. Sundberg, C. Geisler, K. Karjalainen and R.A. Mariuzza. Quantifying the energetics of cooperativity in a ternary protein complex. Biochemistry 41, 5177-5184 (2002).

E.J. Sundberg, Y. Li and R.A. Mariuzza. So many ways of getting in the way: diversity in molecular architecture of superantigen dependent T cell signaling complexes. Curr. Opin. Immunol. 14, 36-44 (2002).

J. Wang, M.C. Whitman, K. Natarajan, J. Tormo, R.A. Mariuzza and D.H. Margulies. Binding of the NK inhibitory receptor Ly49A to its MHC-I ligand: crucial contacts include both H-2Dd and beta2-microglobulin. J. Biol. Chem. 277, 1433-1442 (2002).

C.T. Morita, H. Li, J.G. Lamphear, R.R. Rich, J.D. Fraser, R.A. Mariuzza and H.K. Li. Superantigen recognition by gamma/delta T cells: SEA recognition site for human Vdelta2 T cell receptors. Immunity 14, 331-344 (2001).

M.C. Kieke, E. Sundberg, E.V. Shusta, R.A. Mariuzza, K.D. Wittrup and D.M. Kranz. High affinity T cell receptors from yeast display libraries block T cell activation by superantigens. J. Mol. Biol. 307, 1305-1315 (2001).

Y. Li, H. Li, N. Dimasi, J.K. McCormick, R. Martin, P. Schuck, P.M. Schlievert and R.A. Mariuzza. Crystal structure of a superantigen bound to the high-affinity, zinc-dependent site on MHC class II. Immunity 14, 93-104 (2001).

C.T. Morita, R.A. Mariuzza and M.B. Brenner. Antigen recognition by human gamma/delta T cells: pattern recognition by the adaptive immune system. Springer Semin. Immunopathol. 22,191-217 (2000).

E.J. Sundberg, M. Urrutia, B.C. Braden, J. Isern, D. Tsuchiya, B.A. Fields, J. Tormo, F.P. Schwarz and R.A. Mariuzza. Estimation of the hydrophobic effect in an antigen-antibody protein-protein interface. Biochemistry 39, 15375-15387 (2000).

K. Natarajan, M.W. Sawicki, D.H. Margulies and R.A. Mariuzza. Crystal structure of human CD69: a C-type lectin-like marker of hematopoietic cells. Biochemistry 39, 14776-14786 (2000).

Y. Li, H. Li, R. Martin and R.A. Mariuzza. Structural basis for the binding of an immunodominant peptide from myelin basic protein in different registers by two HLA-DR2 proteins. J. Mol. Biol. 304, 177-188 (2000).

J. Tormo, K. Natarajan, D.H. Margulies and R.A. Mariuzza. Crystal structure of a lectin-like natural killer cell receptor bound to its MHC class I ligand. Nature 402, 623-631 (1999).

P.S. Andersen, P.M. Lavoie, R.-P. Skaly, H. Churchill, D.M. Kranz, P.M. Schlievert, K. Karjalainen and R.A. Mariuzza. Role of the T cell receptor alpha chain in stabilizing TCR-superantigen-MHC class II complexes. Immunity 10, 473-483 (1999).

H. Li, A. Llera, E.L. Malchiodi and R.A. Mariuzza. The structural basis of T cell activation by superantigens. Annu. Rev. Immunol. 17, 435-466 (1999).

H. Li., A. Llera, D. Tsuchiya, L. Leder, X. Ysern, P.M. Schlievert, K. Karjalainen and R.A. Mariuzza. Three-dimensional structure of the complex between a T cell receptor beta chain and the superantigen staphylococcal enterotoxin B. Immunity 9, 807-816 (1998).

H.-M. Li, M.I. Lebedeva, A.S. Llera, B.A. Fields, M.B. Brenner and R.A. Mariuzza. Crystal structure of the Vdelta domain of a human gamma/delta T cell antigen receptor. Nature 391, 502-506 (1998).

H. Li, K. Natarajan, E.L. Malchiodi, D.H. Margulies and R.A. Mariuzza. Three-dimensional structure of H-2Dd complexed with an immunodominant peptide from human immunodeficiency virus envelope glycoprotein 120. J. Mol. Biol. 283, 179-191 (1998).

L. Leder, A. Llera, P.M. Lavoie, M.I. Lebedeva, H.-M. Li, R.-F. Skaly, G.A. Bohach, P.J. Gahr, P.M. Schlievert, K. Karjalainen and R.A. Mariuzza. A mutational analysis of the binding of staphylococcal enterotoxins B and C3 to the T cell receptor beta chain and MHC class II. J. Exp. Med. 187, 823-833 (1998).

B.A. Fields, E.L. Malchiodi, H.-M. Li, X. Ysern, C.V. Stauffacher, P.M. Schlievert, K. Karjalainen and R.A. Mariuzza. Crystal structure of the beta chain of a T-cell receptor complexed with a superantigen. Nature 384, 188-192 (1996).

W. Dall'Acqua, E.R. Goldman, E. Eisenstein and R.A. Mariuzza. A mutational analysis of the binding of two different proteins to the same antibody. Biochemistry 35, 9667-9676 (1996).

G.A. Bentley and R.A. Mariuzza. The structure of the T-cell antigen receptor. Annu. Rev. Immunol. 14, 563-590 (1996).

G.A. Bentley, G. Boulot, K. Karjalainen and R.A. Mariuzza. Crystal structure of the beta chain of a T cell antigen receptor. Science 267, 1984-1987 (1995).