Research Description

Research Area: Marine molecular biology

Research Specialties: Marine actinomycete ecology and molecular biology, microbiology of marine natural products, bacterial and cyanobacterial symbionts of marine sponges, marine bacteriophages, metal resistance in actinomycetes and application in bioremediation.

Research Interests

Marine Microbiology and the Discovery of New Drugs

The major focus of research in my laboratory is the investigation of symbiotic bacteria associated with marine invertebrates, in particular, sponges. Many important compounds with pharmaceutical potential have been discovered in sponges and other invertebrates. In some cases, the compounds of interest are produced, not by the sponges themselves, but by bacteria associated with the sponges. We are identifying many of the bacteria present in sponges even if we cannot grow them, by cloning the genes encoding the 16S ribosomal RNA from these sponges. We can then rationally select culture conditions to be able to grow a higher proportion of the bacteria and, hopefully, find the ones that produce important compounds. We have isolated a Micromonospora sp. strain M42 from the Indonesian sponge Acanthostrongylophora that produces manzamine A, an antimalarial compound found in...

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