Research Overview Biophysical Chemistry
Biophysical Chemistry applies fundamental knowledge and techniques from the field of physical chemistry to large molecules of biological interest, such as proteins and their interactions. The shape, interactions, stability and chemical reactions of In the contextof biological molecules, physical chemistry provides the theory to predict various kinds of energy transfer between large molecules in the cell. Binding of one protein to another, chemical reactions, and changes in shape can be described in... Complete Information... | Research DescriptionResearch Interests: High Affinity Protein Interactions, Structural Metabolic Engineering Biophysical Chemistry My research interests are focused generally on the functional energetics of regulatory proteins. My laboratory uses a range of genetic and biophysical methods to yield structural, kinetic and energetic clues towards elucidating the rules governing molecular control mechanisms in proteins. Two systems are currently being investigated Regulation of catalysis in allosteric threonine deaminase Allosteric enzymes play a pivotal role in cellular regulation by controlling the conversion of substrates to products early in a metabolic pathway. Our efforts on this problem are directed towards forging a quantitative mechanism for the regulation of... Complete Information... |
Representative PublicationsEdward Eisenstein, Kathryn E. Fisher, Hoon Dae Yu, Karin R. Ducote, Dominick A. Iacuzio and Frederick P. Schwarz (1995) "An Expanded Two State Model Accounts for Homotropic Cooperativity in Biosynthetic Threonine Deaminase," /Biochemistry/ *34*: 9403-9412. Zhanglin Lin, Frederick P. Schwarz and Edward Eisenstein (1995) "The Hydrophobic Nature of GroEL-Substrate Binding," /J/. /Biol/. /Chem/.,*270*: 1011-1014. D. Travis Gallagher, Gary L. Gilliland, Gaoyi Xiao, James Zondlo, Kathryn E. Fisher, Diana Chinchilla and Edward Eisenstein (1998) "Structure and Control of Pyridoxal Phosphate-Dependent Allosteric Threonine Deaminase," /Structure/ *6*, 465-475. Complete Listing... |
