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Dr. Ilia Baskakov Representative Publications Print Print   Email Email  

Baskakov, I.V*., Legname, G, Gryczynski, Z., Prusiner, S.B. 2004, The peculiar nature of unfolding of the human prion protein. Protein Science, V.13(3) p. 586-95 (* corresponding author). PMID: 14767078

Baskakov, I.V 2004, Autocatalytic Conversion of Recombinant Prion Proteins Displays a Species Barrier. J.Biol.Chem., V. 279 (9) p. 7671-7677. PMID: 14668351

Legname,G.*; Baskakov,I.V.*; Nguyen,H.-O.B.; Riesner,D.; Cohen,F.E.; DeArmond,S.J.; Prusiner,S.B. 2004, Synthetic mammalian prions, Science, V.305, p 673-676. (*equal contributions). PMID: 15286374

Bocharova, O.V., Breydo, L., Parfenov, A, Salnikov, V.V., Baskakov, I.V. 2005 In vitro conversion of full-length mammalian prion protein produces amyloid form with physical properties of PrPSc. J. Mol. Biol. V.346(2) p. 645-659. PMID: 15670611

Baskakov, I.V., Bocharova, O.V., 2005, In vitro conversion of mammalian prion protein into amyloid fibrils displays unusual features. Biochemistry, V.44, p. 2339-2348. PMID: 15709746

Legname,G.; Nguyen,H.-O.B., Baskakov,I.V.,. Cohen,F.E., DeArmond,S.J., Prusiner,S.B. 2005 Strain-specified characteristics of mouse synthetic prions. Proc. Natl. Acad. Sci. USA, V.102(6) p.2168-2173. PMID: 15671162

Breydo, L., Bocharova, O.V., Baskakov, I.V. 2005 Semi-automated cell-free conversion of prion protein: applications for high throughput screening of potential anti-prion drugs. Analytical Biochemistry, V. 339, p. 165-173. PMID: 15766724

Bocharova, O.V., Breydo, L., Salnikov, V.V., Gill, A.C., Baskakov, I.V. 2005, Synthetic prions generated in vitro are similar to a newly identified subpopulation of PrPSc from sporadic Creutzfeldt-Jakob Disease. Protein Science, V.14(5) p. 1222-1232. PMID: 15802644

Baskakov, I., Disterer, V., Breydo, L., Shaw , M., Gill, A., James, W., and Tahiri-Alaoui, A. 2005, The presence of valine at residue 129 in human prion protein accelerates amyloid formation, Febs Lett, V. 579(12), p. 2589-2596. PMID: 15862295

Bocharova, O.V., Breydo, L., Salnikov, V.V., Baskakov, I.V. 2005 Copper(II) inhibits in vitro conversion of prion protein into amyloid fibrils. Biochemistry, V.44(18), p. 6776-6787. PMID: 15865423

Makarava, N., Parfenov, A., Baskakov, I.V., 2005 Water-soluble hybrid nanoclusters with extra bright and photostable emissions: new tool for biological imaging, Biophys. J., V.89, p.572-580. PMID: 15833997

Breydo, L., Bocharova, O.V., Makarava, N., Salnikov, V.V., Anderson, M., Baskakov, I.V. 2005. Methionine oxidation interferes with conversion of the prion protein into the fibrillar proteinase K resistant conformation Biochemistry, V.44, p.15534-15543. PMID: 16300402.

Bocharova, O.V., Makarava, N., Breydo, L., Anderson, M., Salnikov, V.V., Baskakov, I.V. 2006. Annealing PrP fibrils at high temperature results in extension of a proteinase K resistant core. J.Biol.Chem., V. 281 (4) p. 2373-2379. PMID: 16314415.

Anderson, M., Bocharova, O.V., Makarava, N., Breydo, L., Salnikov, V.V., Baskakov, I.V. 2006 Polymorphism and Ultrastructural Organization of Prion Protein Amyloid Fibrils: An Insight from High Resolution Atomic Force Microscopy. J. Mol. Biol. V. 358, p. 580-596. PMID: 16519898.

Makarava, N., Bocharova, O.V., Salnikov, V.V., Breydo, L., Anderson, M., Baskakov, I.V. 2006 Dichotomous versus palm-type mechanisms of lateral assembly of amyloid fibrils, Prot. Science, V. 15(2), p. 1334-1341. PMID: 16731968.

Novitskaia, V., Bocharova, O.V., Bronstein, I. Baskakov, I.V. 2006 Amyloid fibrils of mammalian prion protein are highly toxic to cultured cells and primary neurons, J.Biol.Chem.V. 281, p. 13828-13836. PMID: 16554307.

Novitskaia, V., Makarava, M., Bellon A., Bocharova, O.V., Bronstein, I. Williamson, A., Baskakov, I.V. 2006 Probing the conformation of the prion protein within a single amyloid fibrils using a novel immunoconformational assay, J.Biol.Chem. V. 281, p. 15536-15545. PMID: 16569635.

Nishina, K.A., Deleault, N.A., Mahal, S., Weissmann, C., Baskakov, I., Riek, R., and Supattapone, S. Glycoform Stoichiometry of Host Protein Regulates Prion Strain Specificity, 2006 Biochemistry, V.45, p.14129-14139. PMID: 17115708

Breydo, L., Sun, Y., Makarava, N., Lee, C.-I., Novitskaia, V., Bocharova, O.V., Kao, J., Baskakov, I.V. 2007 Nonpolar substitution at C-terminus of the prion protein, a mimic of GPI anchor, partially impairs amyloid fibrils formation, Biochemistry, V. 46(3), p.852-861. PMID: 17223707

Sun,Y., Breydo,L., Makarava,N., Yang,Q., Bocharova,O.V., and Baskakov,I.V. 2007 Site-specific conformational studies of prion protein (PrP) amyloid fibrils revealed two cooperative folding domains within amyloid structure. J.Biol.Chem. V. 282(12), p. 9090-9097. PMID: 17244617

Novitskaia, V., Makarava, N., Sylvester, I., Bronstein, I. Baskakov, I.V. 2007 Amyloid fibrils of mammalian prion protein induce axonal degeneration in NTERA2-derived terminally differentiated neurons. J Neurochem. V.102, p. 398-407. PMID: 17472702

Lee, C.I., Yang, Q., Perrier, V., Baskakov, I.V. 2007 The dominant-negative effect of the Q218K variant of the prion protein does not require protein X. Protein Science. 16(10), p. 2166-2173. PMID: 17766375

Makarava, N., Lee, C.I., Ostapchenko, V.G., Baskakov, I.V. 2007 Highly promiscuous nature of prion polymerization. J.Biol.Chem. V. 282, p. 36704-36713. PMID: 17940285

Sun,Y., Makarava,N., Lee, C.I., Laksanalamai, P., Robb, F.T., and Baskakov,I.V. 2008 Conformational stability of PrP Amyloid Fibrils Controls Their Smallest Possible Fragment Size. J.Mol.Biol. V. 376, p. 1155-1167. PMID: 18206163

Makarava, N., Baskakov, I.V. 2008 The same primary structure of the prion protein yields two distinct self-propagating states. J.Biol.Chem. V. 283, p.15988-15996. PMID: 18400757

Makarava, N., Baskakov, I.V. 2008 Expression and purification of full-length recombinant PrP of high purity. Methods Mol Biol. V.459, p.131-43. PMID: 18576153

Breydo, L., Makarava, N., Baskakov, I.V. 2008 Methods for conversion of prion protein into amyloid fibrils. Methods Mol Biol. V. 459, p.105-115. PMID: 18576151

Ostapchenko, V., Makarava, M., Savtchenko, R., Baskakov, I.V., 2008, The polybasic N-terminal region of the prion protein controls the physical properties of both the cellular and fibrillar forms of PrP, J.Mol.Biol. V. 383, p. 1210-1224. PMID: 18789949

Makarava, M., Ostapchenko, V., Savtchenko, R., Baskakov, I.V., Conformational switching within individual amyloid fibrils. 2009 submitted to J.Biol.Chem. PMID: 19329794

 

 

 

 

 

 

 

 

 

 

 

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